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KMID : 0369820160460040317
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Jorunal of Korean Pharmaceutical Sciences
2016 Volume.46 No. 4 p.317 ~ p.324
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Polymeric materials for drug release system in drug eluting stents
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Seo Jeong-Deok
Lee Jong-Hwan
Na Kun
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Abstract
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Bare metal stents (BMSs) have been studied in the treatment of tubular organ occlusion, but restenosis remains a problem with this type of therapy. Drug eluting stents (DESs) were developed afterwards to treat and prevent re-stenosis. Clinical studied have proven the efficacy of DESs for the prevention of smooth muscle and cancer cell proliferations. Coating DESs with a polymer facilitates sustained drug release by diffusion, degradation, and osmosis. To control drug delivery in DESs, the drug and polymeric materials-including their physicochemical properties-must be taken into consideration. It is important to understand polymeric materials for the development drug delivery technologies. This review highlights the studies on drug delivery system based on polymeric material used in DESs and the role of polymeric materials in DESs for drug delivery.
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KEYWORD
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Polymeric materials, Drug release control, Drug eluting stent, Polymer coating
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